Ketamine hydrochloride, also known as Special K, Kit-Kat, or simply K, belongs to a class of drugs called dissociative anesthetics. These drugs, which also include nitrous oxide and phencyclidine PCP , separate perception from sensation. Ketamine was created to be an anesthetic. Doctors still use it for general anesthesia in certain circumstances. The Food and Drug Administration FDA also recently approved a nearly identical drug, esketamine , for treatment-resistant depression. In higher doses, it can produce dissociative and hallucinogenic effects, which are collectively called a K-hole or K-holing.

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Top definition. To have used to much of the drug ketamine special K and lost sense of time and space, balance , verbal skills. It took Dave 10 minutes to walk up the steps he was in such a K hole. Only noobs think that k holing is overdosing on ketamine when in actual fact, people with experience know that its the best bit. Yesmate, you get the film and projector while I'll make lines - for the ultimate k hole cinema :D. I hope this puts me in a k hole, i would like to be flown through the ceiling into another room, preferably with a laser blue conveyor belt. An experience that can be triggered by higher doses of ketamine that can bring back memories and flashbacks through intense hallucinations. The user will feel disassociated and will most likely not be able to physically move. After experiencing the K-hole , users may feel enlightened or spiritually awakened. Man, last night was crazy , I got lost in the K-hole.
Ketamine is a dissociative drug. It is used as an anesthetic and more recently in the treatment of certain depressive disorders. In simple terms, dissociative drugs make users feel detached from reality and themselves. These feelings of dissociation get more intense at high doses, causing people to feel disconnected from or unable to control their own bodies, including the ability to speak and move around easily. One way to think about a k-hole is a state between intoxication and a coma.
Ketamine has a history of saving people's lives. Long before your cousin was snorting K off a key at a bush doof, medics were using it as an anaesthetic in the jungles of Vietnam. And, in more recent years, medical professionals have been extolling the benefits of the horse tranquilliser for its effects on treatment-resistant depression , anxiety , and PTSD. So what about K-holes , then? That dark frontier of the human psyche where the ego dissolves and the individual starts wondering if they're dead.